Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer
نویسندگان
چکیده
منابع مشابه
DNA hybridization in thermoresponsive polymer nanoparticles.
We achieve very high hybridization efficiencies by using a new method to immobilize DNA strands on the surface of thermoresponsive polymer nanoparticles. Hybridization efficiencies of about 70 % are obtained between the DNA immobilized in the particles and a complementary strand in solution, even at very low ionic strengths (1 mM). The polymer nanoparticles have a glassy poly(methylmethacrylate...
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BACKGROUND Deoxyribonucleic acid (DNA) vaccines are used for experimental immunotherapy of equine melanoma. The injection of complexed linear DNA encoding interleukin (IL)-12/IL-18 induced partial tumour remission in a clinical study including 27 grey horses. To date, the detailed mechanism of the anti-tumour effect of this treatment is unknown. RESULTS In the present study, the clinical and ...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2007
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2007.08.026